There are several causes of Arthritis ranging from injuries to ageing to autoimmune disorders. But, one core reason that is quite common is the DNA makeup of an individual. DNA or deoxyribonucleic acid is like a code that acts as an instruction manual for making all the proteins in our bodies and helping them thrive. The information coded in DNA is hereditary which means that it is passed down from parent to child. So, in case you have a question such as, “Is arthritis hereditary?” Then, the answer is yes, sometimes.
So, in case your ancestors had an Arthritis condition, there are chances that it might be passed down to you as well. This is the core reason why knowing your ancestral health information via DNA mapping is crucial for identifying the risks of getting Arthritis, potentially preventing its onset, and managing the condition.
In this article, we'll delve into the intricate relationship between arthritis and genetics. You can explore how your DNA can influence the development and progression of this debilitating disease.
Role of DNA in Arthritis Development
The genetic risk of Arthritis is real. At the core of the link between arthritis and genetics is DNA. It is the genetic material that comprises the instructions for the development and function of every cell in your body. Certain variations or mutations in your DNA might lead to protein production that trigger the inflammatory processes and cause joint damage associated with arthritis. Thus, understanding Arthritis genetics of your DNA is crucial, especially of your ancestors, to gauge what are the chances of you getting this condition.
Researchers across the world have identified specific gene variants that are primarily involved in the regulation of the immune system. This can influence the body's response to joint-related infections or injuries - leading to the development of autoimmune forms of arthritis, such as rheumatoid arthritis. Additionally, genetic factors in arthritis can also play a role in the structural integrity of the joints.
Types of Arthritis with a Genetic Component
Given below are some of the Arthritis conditions that occur in our body in case of genetic issues.
- Rheumatoid Arthritis (RA): Rheumatoid arthritis is an autoimmune disorder in which the body's immune system mistakenly attacks the joints. Thus, leading to pain, inflammation, and joint damage. There are many genetic variations, such as those in the HLA-DRB1 gene, that have been linked to an increased risk of developing RA.
- Osteoarthritis (OA): Osteoarthritis is considered to be the most common form of arthritis. It is caused due to the breakdown of cartilage in the joints. While genetics play a key role, environmental factors, such as weight, age, and injury, also contribute to the development of OA.
- Psoriatic Arthritis (PsA): Psoriatic arthritis is a type of inflammatory arthritis that occurs in individuals with the skin condition psoriasis. Genetic factors, particularly variations in the HLA-B27 gene, have been associated with an increased risk of developing PsA.
- Ankylosing Spondylitis (AS): Ankylosing spondylitis is another type of inflammatory arthritis that affects the spine and sacroiliac joints. The HLA-B27 gene has been strongly linked to an increased risk of developing AS.
Understanding the types of Arthritis you might get based on your genetic markup can help you manage arthritis conditions better in the future.
Identifying Genetic Predisposition to Arthritis
Understanding your arthritis genetic predisposition will give you a clear idea of how vulnerable you are of getting this condition. Advances in research and genetic testing have made it possible to pinpoint the genetic markers that can indicate an increased risk of developing certain types of arthritis.
With the help of genetic testing, you can gain insights into your genetic profile and the potential risk factors associated with arthritis. Based on this information, you can fight arthritis that is hereditary in nature in the following ways -
- Engaging in joint-friendly exercises to maintain mobility and strength.
- Following a healthy, nutrient-rich, & anti-inflammatory diet to support overall joint health.
- Seeking early medical intervention & monitoring your condition for effective prevention.
- Another way that can be explored is by participating in clinical trials or research studies that may lead to the development of new, targeted treatments. The role of your DNA in arthritis can prove to be significant in achieving a new breakthrough.
To learn more about your genetic risk for arthritis and explore personalised management strategies, start taking proactive steps towards managing your joint health. You can get three60+ Daily Joint Care & Protect tablets to strengthen your bones, improve mobility, and get joint pain relief.
In conclusion, the link between arthritis and genetics follows a complex and multifaceted relationship that continues to be the focus of extensive research. Taking precautionary steps will ensure that you are one step ahead of the Arthritis condition and your joint remains in excellent shape!
